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Abstract INTRODUCTION SEARCH STRATEGY EXISTING RESCUE THERAPIES FOR ASUC CHALLENGES IN SELECTING THE RIGHT RESCUE THERAPY IN ASUC MECHANISMS OF INFLIXIMAB FAILURE MECHANISMS OF CYCLOSPORIN FAILURE IN ASUC SEQUENTIAL THERAPY MAINTENANCE THERAPY FOLLOWING SUCCESSFUL INDUCTION OF REMISSION IN ASUC WHEN TO CONSIDER COLECTOMY DISCUSSION CONCLUSIONS AND FUTURE DIRECTIONS NOTES REFERENCES Abstract Acute severe ulcerative colitis (ASUC) is a medical emergency that affects approximately 25% of patients with ulcerative colitis at some point in time in their lives

on activation they upregulate the myogenic regulatory factor MyoD, proliferate as myoblasts, and only later express myogenin as they commit to differentiation and fusion

While this assumption is convenient for mathematical purposes, it may not always hold in reality as the distribution of true effect sizes across different studies could have any shape

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