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17 A study conducted by Zhou and colleagues, 18 which included PDAC patients (32), autoimmune pancreatitis patients (32), and healthy controls (32), showed a marked increase in the phylum Proteobacteria and a decrease in the phylum Firmicutes in PDAC patients compared to autoimmune pancreatitis patients and controls

Although the specific mechanism is not completely clear at present, from the perspective of its important regulatory role on GABAergic neurons, the abnormality of ARX may affect the normal development and function of GABAergic neurons, leading to the imbalance of brain neural circuits, thus causing ASD related symptoms ( Dysfunction of GABAergic interneurons has been observed in animal models of ASD