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Particularly, the targeting of proteins such as PTEN-induced kinase 1 (PINK1), Parkin RBR E3 ubiquitin-protein ligase (PARKIN1), cAMP-response element binding protein (CREB), and tropomyosin receptor kinase B (TrkB) through docking techniques holds immense importance in comprehending the pathogenesis of PD [20]

Diarrhoea (defined as three or more loose or watery stools per day) is an uncommon side effect of vitamin B12 supplementation , though it is listed as a rare or uncommon adverse reaction in the official product information for both oral cyanocobalamin and injectable hydroxocobalamin preparations

Also, G.S.Z declares that he was a blinded research subject in this study

6.2.2 Liquid biopsy: role of circulating tumor DNA and exosomal miRNAs Liquid Biopsy is an advanced and emerging form of non-invasive and dynamic technique that detects and analyzes the biomarkers present in the bloodstream for the genotyping of an existing tumor