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Archived from the original on 2017-08-25

34,37 The requirement for local metabolic activation of NNK in the mouse lung has been elegantly demonstrated by experiments using mice in which cytochrome P450-reductase, the requisite co-factor for cytochrome P450-catalyzed metabolic activation of NNK, has been knocked out in the lung, 38 and a polymorphism in Cyp 2A5 decreased NNK-induced DNA adduct formation and lung tumorigenesis, as seen in parallel epidemiologic studies of lung cancer

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