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Renal insufficiency, indicated by serum creatinine levels of 1.5 mg/dL or higher in men and 1.4 mg/dL or higher in women, is a contraindication for metformin therapy

The oki1 weak mutant phenotype differed from most meristem mutations, in that the cellular organization was highly irregular, and suggest that it may function through a different mechanism compared to the canonical meristem pathways

One of the most striking observations from these studies is that only a small fraction of the signalling changes seen in insulin resistance involved canonical insulin signalling proteins [3234]

It is due to the itchy patch at the site of entry that the early infection gets its nickname ground itch