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doi: 10.1007/s11064-012-0963-2 46 FoL.MotaS

In evolutionary terms, it is a way of saying enough. If you then layer on therapies like exogenous insulin, you can temporarily force glucose down, but you havent changed the reason the resistance developed in the first place

Reviewer information Nature Reviews Disease Primers thanks P

[DOI] [PMC free article] [PubMed] [Google Scholar] [26].Ribatti D, Solimando AG, Pezzella F, The anti-VEGF(R) drug discovery legacy: improving attrition rates by breaking the vicious cycle of angiogenesis in cancer, Cancers (Basel) 13 (14) (2021)