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Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management

Think of parts per billion as 1 drop of water in an Olympic sized swimming pool

10.1158/0008-5472.CAN-07-0783 180 XuY.XinY.DiaoY.LuC.FuJ.LuoL.et al (2011)

The expression and activity of ACLY are significantly upregulated in several malignancies such as bladder, breast, lung, liver, stomach, prostate, and colon cancers (12, 1418), and the overexpression of ACLY correlates with poor prognosis in lung adenocarcinoma and blood cancers (15, 19)