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Live cell metabolic profiling showed that prolonged netrin-1 signaling (through SFK activation and ROCK inhibition) hyperpolarizes the mitochondrial inner membrane and increases glycolysis but not OXPHOS in primary OLs (Nakamura et al., Oligodendrocyte NMDA Receptor Activation Increases Glucose and Lactate OLs are known to provide trophic and metabolic support to the axons they ensheath, yet variations in synaptic strengths and neuronal firing rates can greatly alter the metabolic demand of axons

doi: 10.1111/j.1365-2605.2011.01218.x 92 HiroseMHondaAFulkaHTamura-NakanoMMatobaSTomishimaTet al

However, this response is often a sign that the bacterial overgrowth is being successfully addressed

Due to the lack of a single test capable of confirming or excluding WD, diagnosis is frequently difficult and delayed