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Elevated intracellular amphetamine also activates trace amine-associated receptor 1 (TAAR1), leading to protein kinase A (PKA) and protein kinase C (PKC) signaling and phosphorylation of DAT, NET, and SERT (Step 3)

In addition to the previous review on Curculigo orchioides [2], there has been a new findings of pharmacological properties on this plant that is the anti-diarrheal activity in the recent studies reported by the researchers [114, 115]which is also an another prove that among this genus, Curculigo orchioides is the most relevant ethno-medicinal herb

Bulk RNA sequencing was also performed on control non-disease and PSC patient-derived cholangiocytes

Standardized methodologies, comprehensive exposure assessment, detailed mechanistic understanding, and longitudinal epidemiological data are needed to establish microplastics as a causative factor in dementia pathogenesis and to inform effective intervention strategies