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Figure 13 summarizes key intracellular glutathione (GSH) sensing strategies, encompassing fluorescent probes that detect reduced GSH through light emission, enzymatic biosensors that generate electrical signals via GSHNAD(P)H redox cycling, quantum nanoprobes that enable high-resolution fluorescence shifts, and nanomaterial-based sensors that act as GSH-responsive reporters for gene editing and signal amplification

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however, few studies have investigated the specific upstream and downstream regulation of TCM