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A rational method of prioritizing drugs and drug targets with a metabolic network as an underlying framework also provides for a possible mechanism of action for many of the drugs selected (e.g., the network model enables the analysis of what biosynthetic pathways are inhibited when a particular enzyme's function is pharmacologically inhibited)

DSIP is not approved by the FDA or any other major health authority

Patients with elevated nighttime inflammatory markers may benefit from evening dosing to support circadian repair, while those with daytime oxidative stress show better response to morning protocols that preload antioxidant defenses before peak exposure hours

IRF3 inhibits nuclear translocation of NF-B to prevent viral inflammation