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However, it is important to emphasize the fact that the skin is the only organ exposed to the external environment, especially areas such as the face, neck, hands, and arms, which reflect both chronological and photoaging [9]

Dysregulated nocturnal cortisol rhythms interfere with slow-wave oscillations and sleep spindles during non-rapid eye movement (NREM) sleep, thereby exacerbating the severity of insomnia

Oxalic acid and oxalate crystals are thought to cause host tissue damage (including in pulmonary blood vessels), as well as tissue injury via iron-dependent generation of free radicals (157, 163)

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