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The most common adverse reactions include insomnia, flatulence, constipation, weight gain, vomiting, diarrhea, increased aggression, and seasonal allergy exacerbation

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In addition, quantification of astrocytes and glial cells revealed that it is reduced in the prefrontal, orbitofrontal area and anterior cingulate, entorhinal and subgenual cortex, and amygdala of the brain investigated from the samples derived from patients with debilitating depression and bipolar disorder (Verkhratsky et al., 2019a,b)

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