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Contrary to other cytokines targeted into the conventional secretory pathway, leaderless IL-1 is exposed to cytosolic post-translational modifications

Amplified cDNA libraries were prepared using the NEBNext Ultra II FS DNA Library Prep Kit for Illumina (New England Biolabs, # E7805), and sequenced on an Illumina NovaSeq 6000 system (Illumina, # 20012850) with either NovaSeq 6000 S4 Reagent Kit v1.0 (Illumina, # 20027466) or v1.5 (Illumina, # 20028313), generating 200-cycle paired-end reads (read1: 67 bp, read2: 155 bp)

Studies indicate that natural antioxidants like vitamin E, vitamin C, and beta-carotene may help scavenge free radicals that emerge during the diseases progression [14]