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Dpp is expressed in a stripe abutting the A/P compartment boundary and forming a precise concentration gradient along the A/P axis 19,20,21,22

The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

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A group receiving annual administrations of both peptides for six years saw a 4.1-fold reduction in mortality compared to controls, highlighting their potential research interest in the context of prolonged active longevity