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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Martina JA, Chen Y, Gucek M, Puertollano R

Many studies have found that carotenoids can affect the expression of cell cycle-related proteins, such as increasing the levels of the cell cycle inhibitors p21Cip1 and p27Kip1, while inhibiting the activity of Cyclin and its related kinases, thereby inducing cell cycle arrest in cancer cells ( In addition to inhibiting proliferation, carotenoids affect the cellular DNA damage response pathway, enhancing p53-mediated gene monitoring and repair

In this way, Bax may stop apoptosis from happening while Bcl-2 helps it happen and both caspase-3 and caspase-9 can stop Bcl-2 from doing its job