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Randomized phase II study of modified FOLFOX-6 in combination with ramucirumab or icrucumab as second-line therapy in patients with metastatic colorectal cancer after disease progression on first-line irinotecan-based therapy

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Among them, system Xc (including SLC7A11 and SCL3A2), which are expressed at the cell membrane, are easier to be detected as a cell surface marker of cells undergoing ferroptosis

Additionally, few studies use standardised symptom scales or evaluate long-term clinical endpoints such as fatigue, cognitive function, or sustained quality of life improvements