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Weight loss is both psychological and physiological

This explains why some individuals require intramuscular B12 injections or high-dose oral supplements to bypass the compromised absorption mechanism

However, such studies do acknowledge that conflicting results exist, with one study specifically suggesting that increased B12 intake may lead to a quicker falling off of melatonin and a shorter sleep duration

[10] [11] [12] [13] [14] Rich Van Konynenburg first postulated a depletion of glutathione was at the heart of many of the symptoms of CFS/ME, but quickly added information about methylation when he realized that the two were connected