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Sultr4;1 mutant seeds of Arabidopsis have an enhanced sulphate content and modified proteome suggesting metabolic adaptations to altered sulphate compartmentalization

This use was associated with the production of short-chain fatty acids, such as acetate 40

These hallmark abnormalities disrupt synaptic communication, trigger neuroinflammation, and promote neuronal apoptosis, collectively leading to extensive neurodegeneration and cognitive dysfunction

Finally, unilateral orchidectomy, although adopted to reduce animal use and allow intra-subject comparison, may influence hormonal balance and induce compensatory changes in the contralateral testis