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In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis (Yang et al., 2014)

10.1159/000021313 Boebel KP, Baker DH: Blood and liver concentrations of glutathione, and plasma concentrations of sulfur-containing amino acids in chicks fed deficient, adequate, or excess levels of dietary cysteine

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Higher doses of the seed extract (500, 1,000, and 2,000 mg/kg) resulted in death rates of 20%, 60%, and 80%, respectively