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Further research is needed to improve our understanding of their effects on obesity-related comorbidities and the underlying mechanism, whether involving direct effects on target tissues or mediated by improvement in BW, glucose levels and other CV risk factors

Second, many available studies are characterized by small sample sizes or lack appropriate control groups, making it difficult to draw definitive conclusions about therapeutic efficacy and optimal treatment protocols

Research spanning three decades demonstrates regenerative effects across multiple organ systems

Contrary to expectations 86 , CV event rate (including stroke) in SELECT was in line with that described in GLP-1RA CVOT conducted in patients with diabetes 84,85