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Use of thiols in the treatment of COVID-19: current Evidence

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The most commonly reported adverse events in the Phase 2 trial were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the GLP-1 receptor agonist class

AF9, a paralog of ENL that is also bound by this chemical series 30 , was too lowly expressed in MV4;11 cells to evaluate degradation by proteomics, but an immunoblot analysis of endogenously expressed AF9 suggests it can also be degraded by dHTC1 (Extended Data Fig