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Together with the absence of symptoms associated with IGF-1-mediated effects such as fluid retention, tissue edema, or impaired glucose tolerance, these results demonstrate that AOD-9604 does not activate the growth hormone/IGF-1 pathway and therefore functions through an entirely appetite-independent mechanism

But is supplementation enough and is it safe long term

By binding to substances that need to be excreted, it helps the kidneys to excrete these wastes more easily

Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress