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LE BOUFFANT, L., MARTIN, J.C., DANIEL, H., HENIN, J.P., & NORMAND, C

If the amount of sodium in the body is high, the amount of potassium required by the body increases

Collectively, these data suggest ndufs2 -/- zebrafish have enlarged livers with increased yolk lipid accumulation due in part to impaired FAO flux, owing to their upregulated NADH:NAD + ratio that is caused by their genetically-disrupted CI (NADH dehydrogenase) capacity and was likely exacerbated by disrupted one-carbon metabolism in the liver, as in mouse liver NAD(P)H is derived from serine catabolism (4, 34, 64)

The formulation process introduces variables that affect how much active peptide actually reaches the dermal target tissue