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Drugs 29 , 12951308 (2020)

Fragment 176-191 has been heavily researched in animal models because even while it preserves the fat-burning effects of hGH, it avoids some other effects of its parent protein such as increasing insulin-like growth factor-1 (IGF-1) levels, negatively impacting carbohydrate metabolism, altering insulin sensitivity, increasing long bone growth, and so forth

Preclinical data shows weight reduction occurs even in ad libitum feeding conditions, meaning caloric intake isn't restricted