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Fatigue is intrinsic to multiple sclerosis (MS) and is the most commonly reported symptom of the disease

Changes in brain metabolism might contribute to these phenotypes, as many of the deleted genes are involved in metabolic processes, but this is unknown

Moreover, MG derivative MG-H1 down-regulates PD-L1 expression in tumor cells in metastatic prostate cancer (mPCa), whereas high expression of GLO1 limits the accumulation of MG-H1 and maintains the expression of PD-L1, which inhibits CD8 T cell function and promotes immune escape in mPCa

This relationship has also shown that GSH depletion impairs dendritic cell mediated T-cell activation, further hindering immune response (Kim et al., 2007)