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Ipamorelin hits the GHRP receptor and says "release GH now." CJC-1295 (no DAC) hits the GHRH receptor and says "amplify that release." When dosed together: CJC-1295 primes the pituitary and increases the available pool of GH Ipamorelin triggers the acute release of that pool The combined pulse is substantially larger than either compound generates alone research suggests synergistic effects in the range of 210x depending on baseline GH status and dosing This works because the two compounds bind to completely separate receptors

Competing interests: Authors Doyle, Kavanagh, Schrettl, Carberry and Haas are co-inventors on a patent application derived, in part, from the work presented in this manuscript

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Berberine alleviates ulcerative colitis by inhibiting inflammation through targeting IRGM1