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This condition presents with failure to lactate, amenorrhea, and secondary hypothyroidism due to decreased production of TRH or TSH

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Among the reasons for using cell culture(s) to study CoQ uptake and trafficking are the high degree of specificity with which one can control their environment, the ease and accuracy of administration of nutrients, hormones, and in this case CoQ, the decreased physiological variability as compared to live animals

Cells may exhibit some atypia, with enlarged nuclei or even giant nuclei with one or two nucleoli