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Other medications that will deplete this vitamin include: Metformin Antibiotics Methotrexate Colchicine Anti-seizure medications Cholestyramine Corticosteroids Others at risk are: There are various other reasons someone may develop a B12 deficiency, including: People who consume caffeine daily Chronic Alcohol users People consuming processed food or junk food regularly Smokers and potentially vapers Women taking oral contraceptives or birth control pills What Medical Conditions Can Cause B12 Deficiency