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& Lerch, R

Furthermore, compromised mitochondrial function may be reflected in aberrant oxidative metabolism, down-regulated adenosine triphosphate-dependent proteasome degradation, and ensuing DNA damage contributing to neuronal apoptosis (270, 272)

Nature 360 , 225231 (1992)

Research has shown that depressed patients with multiple depressive episodes have low hippocampal volume, thus marking the importance of studying inflammation and its neurodegenerative properties