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Disclosures: Shreya Kishore: Nothing to Disclose, Orlee Guttman: Mirum: Consultant 2473 MECHANISM OF LAURIC ACID-MEDIATED HEPATOBILIARY PROTECTION DURING ACUTE INFLAMMATORY CHOLANGIOPATHY IN MICE Swati Ghosh 1 Michael Devereaux 2 Aimee Anderson 2 COLIN ANDERSON 2 ANGELO D'ALESSANDRO 2 David Orlicky 2 Ronald Sokol 1 , 1 University of Colorado School of Medicine, 2 University of Colorado School ofMedicine Background: Primary sclerosing cholangitis causes cholestasis, inflammation and fibrosis of bile ducts

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Both responses are normal

Setting realistic expectations is crucial for long-term success