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In this study, we have used cryo-EM to determine the 3.4 and 4.0 resolution structures of endogenously phosphorylated Saccharomyces cerevisiae Ycf1 in two inward-facing conformations: wide (IFwide) and narrow (IFnarrow)

Glucosylsphingosine promotes alpha-synuclein pathology in mutant GBA-associated Parkinsons disease

Key Takeaway: A lower dose with high bioavailability is often more effective than a high dose that the body cannot properly absorb