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Patients taking clonidine should be aware of the importance of adhering to prescribed dosages, as the medication works by stimulating alpha-2 adrenergic receptors in the brain, which can significantly lower heart rate and blood pressure

Long-term alcohol use can damage the liver, cause inflammation and scarring, and lead to liver failure

Rev Endocr Metab Disord (2016) 17:47184

Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study