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Collagen and ECM Synthesis GHK-Cu directly stimulates collagen synthesis in human dermal fibroblasts at nanomolar concentrations, with stimulation beginning between 10 12 and 10 11 M and maximizing at 10 9 M (PMID: 3169264, FEBS Letters , 1988)

Furthermore, it impairs the IEB and makes it more permeable, which opens the door for bacterial toxins to enter the bloodstream (2, 99104)

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Cellular processes enhanced by GHK-Cu include fibroblast proliferation, keratinocyte migration, and endothelial cell growth