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It operates as an indirect-acting sympathomimetic, triggering the release of norepinephrine from presynaptic vesicles in the lateral hypothalamus

Dual-pathway GH stimulation: in published endocrinology research, GHRH-receptor agonism (CJC-1295) and ghrelin-receptor agonism (ipamorelin) act through complementary intracellular pathways, with the combination producing larger GH pulses than either alone in animal model and isolated pituitary cell research