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In both and settings, curcumin and its reduced metabolites undergo conjugation with glucuronic acid and sulfate

J Appl Toxicol JAT 32:505520 Laaksonen R, Katajamaa M, Piv H, Sysi-Aho M, Saarinen L, Junni P, Ltjohann D, Smet J, Van Coster R, Seppnen-Laakso T, Lehtimki T, Soini J, Orei M (2006) A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle

Keywords: CYP450, liver metabolism, lipid accumulation, monooxygenases, alcoholic fatty liver disease, non-alcoholic fatty liver disease Introduction Liver metabolism disorders are primarily caused by an imbalance in lipid metabolism, which leads to the excessive accumulation of triglycerides (TG) and cholesterol (CHOL) in the liver

Heliyon, 10 (4), e25590