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The discrepancies between the results of the various studies might be related not only to the dose of l-ARG or the period of l-ARG supplementation, as well as the population cohort and the study design, but also to the methodology used for the assessment of ED, which was relevantly different among the studies

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The target genes for the antioxidant response encode a set of enzymes and other proteins that scavenge free radicals, neutralise electrophiles or up-regulate the critical cellular thiol, glutathione

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