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Basing that, we assumed this discrepancy stemmed from the inability of co-culture system in vitro to fully simulate in vivo cellular communication dynamics, and which may be caused by the low concentration of interleukins from original pyroptotic hepatocytes in the co-culture system, which was insufficient to drive M1 polarization of macrophages

Minor bruising at the IV insertion site is possible but uncommon when placed by experienced clinical staff

Interestingly, tails with six Ala residues appeared to be a sweet spot as peptides containing a A 5 -NH 2 (MP-685) or an A 7 -NH 2 (MP-470 and MP-471) motif had slightly worse cellular activities in the presence of serum (Table 1)

Notably, the expression of B-cell lymphoma 2 (Bcl-2) was significantly downregulated, leading to apoptosis of spermatocytes [108]