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497 Moreover, with respect to calcific aortic valve diseases, which is one of the most widespread heart valve disorders, the expression of ZIP13 is markedly enhanced

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Nevertheless, the immunosuppressive tumor microenvironment (TME) in HCC, characterized by the abundance of inhibitory cytokines (e.g., IL-4, IL-10, and IL-13) can educate the infiltrating macrophages toward an M2 phenotype, thereby attenuating the antitumor immune response and promoting tumor progression [19, 20]

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