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in: PubMed | Google Scholar | 1 Department of Molecular and Integrative Physiology, 2 Department of Internal Medicine, Division of Gastroenterology, 3 Rogel Cancer Center, and 4 Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA

An important caveat to our maps is that, because the underlying complementation assay is based on expression of mature cDNA, they cannot detect the impact of variants on splicing

Upon bacterial infection, WRS is secreted by the monocytes, and directly binds to macrophages via a toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex, inducing phagocytosis and chemokine production ( in vitro and in vivo (Lee et al., 2019)

Hydrolysis of SAH yields homocysteine, which is converted to cystathionine, cysteine, and finally to glutathione, the hepatocellular antioxidant and life-saving detoxification agent