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Participants receiving the highest dose (1.0 mg) achieved a mean weight loss of 10.6%, while those in the placebo group experienced a mean weight loss of only 2%

The original trigger is viral injury to the sensory nerve, but chronic pain may also involve peripheral sensitization, dorsal root ganglion irritation, central sensitization, local muscle spasm, trigger points, low-grade inflammation, sleep disturbance, and systemic factors such as diabetes or nutritional deficiencies

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Pharmacogenomics J (2008) 8:35763.10.1038/tpj.2008.1 39 PetersennSHeyensMLdeckeDKBeilFUSchulteHM