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One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition

This makes them incredibly appealing for individuals who may already have their diet locked in, but still face metabolic resistance or stubborn pockets of tissue

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Higher absorption rate The intramuscular injection method ensures a 95% absorption rate compared to oral supplements, which have only 50% absorption