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Using both is redundant rather than synergistic and may cause NAD+ oversupply, which preliminary research suggests could impair SIRT1 regulation

In this blog, well look at how each treatment works, the key differences between them, and how to know which option is best suited to you

Jepson et al

Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome