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Furthermore, keratinocyte apoptosis has also been reported to occur in response to high concentrations of arsenic through FAS ligand pathways (Liao et al

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Overall, there was a transient increase in serum creatinine observed within 10 days of dosing in 1.8% of Reclast-treated patients versus 0.8% of placebo-treated patients which resolved without specific therapy [see Warnings and Precautions (5.3)]

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