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The effect and safety assessment of metformin and DLBS3233 (a bioactive fraction of Lagerstroemia speciosa and Cinnamomum burmannii ) on improving metabolic parameters in women with polycystic ovary syndrome

Receptor binding and signaling assays demonstrate that AOD 9604 does not activate the growth hormone receptor, distinguishing it from full-length GH

These findings may open the door to using FDA-approved medications in combination therapy protocols to treat highly resistant malignancies and improve the efficacy of chemotherapy treatment

These resistances reduce the long-term effectiveness of treatments, underscoring the need for novel therapies or combination strategies to overcome them