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(Lee et al., 2005) documented significantly elevated NNMT expression in abdominal subcutaneous adipocytes of obese Pima Indians relative to non-obese counterparts

208 An open crossover trial in 22 subjects with fibromyalgia found 200 mg of CoQ10 (as ubiquinone) twice daily (in a supplement that also contained vitamins B2, B6, B9, B12, and E) for three months reduced pain, fatigue, and sleep disturbance compared with no treatment

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However, the full benefits, including improved mood, enhanced mental clarity, and better metabolism, typically develop over 2-3 weeks of consistent treatments