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Importantly, the enzyme does not respond to SAM stimulation

As summarized in Figure 4, these bioactivities position BSPs as promising candidates for nutraceutical and pharmaceutical development

The blockade of ERK1/2 activation by U0126 (a MAPK kinases inhibitor) attenuated the IRE1 level, suggesting that ERK1/2 activation causes ER stress activation in PFOS-treated RTCs (Fig