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They enhance the effect of EGF on DNA synthesis and prevent transglutaminase 2 (TG2)-mediated transamidation of the EGFR in hepatocytes by binding to 1-adrenergic receptors (1-ADR) 182,589,590 Additionally, other research suggests that catecholamines also support the proliferation of cholangiocytes and LPCs

(2010) 125:AB6

The effect of dual bioactive compounds artemisinin and metformin co-loaded in PLGA-PEG nano-particles on breast cancer cell lines: potential apoptotic and anti-proliferative action