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176 It noted that whilst formularies identify vitamin B 12 deficiency as a possible side effect of metformin, there is a lack of guidance relating to the investigation of the risk, despite there being a deficiency prevalence of 17% in the study cited in the editorial

Similar observations have already been reported, e.g

Based on existing literature, an N of 6 was initially tested for DMRS in both groups and the fMRI group of GLP-1R KO mice, an N of 7 for PET in both groups [30,31,32,33], and an N of 6 for both groups for cyclic adenosine monophosphate (cAMP) measurement

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