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Description

CDKN2A CDKN2A is a gene encoding the P16 protein, which binds to CDK4 and CDK6 and inhibits the formation of kinase-active complexes between CDK4 and cyclin D, thereby regulating the cell cycle and arresting cells in the G phase [67, 68]

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SG-55 is a selective, noncompetitive and orally active AKR1C3 inhibitor with an IC 50 of 5 nM and a K i of 10 nM

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